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KMID : 0357920100440040390
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Korean Journal of Pathology
2010 Volume.44 No. 4 p.390 ~ p.396
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Clinicopathological Significance of Invasive Ductal Carcinoma with High Prevalence of CD44+/CD24-/low Tumor Cells in Breast Cancer
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Sung Ji-Youn
Kim Gou-Young
Park Yong-Koo
Lee Ju-Hie
Kim Youn-Hwa
Lim Sung-Jig
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Abstract
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Background: Epithelial tumor cells with a CD44+/CD24-/low immunoprofile may have the ability to cause breast cancer. We studied these cells and their clinicopathological significance.
Methods: The clinicopathologic findings of 100 invasive ductal carcinoma (IDC) cases and 45 ductal carcinoma in situ (DCIS) cases were reviewed. CD44+/CD24-/low tumor cells were identified by immunohistochemistry, and their clinicopathological implications in IDC and DCIS were analyzed.
Results: IDC with a high prevalence of CD44+/CD24-/low tumor cells was significantly associated with larger mass, higher grade, estrogen receptor (ER) negativity, and tumor cells with a higher frequency of metastasis. The proportion of CD44+/CD24-/low tumor cells in IDC, and its DCIS components was not significantly different, whereas the proportion of CD44+/CD24-/low tumor cells was higher in DCIS than in the DCIS component of IDC (p < 0.001).
Conclusions: IDC with a high prevalence of CD44+/CD24-/low tumor cells might correlate with aggressive features, such as ER and higher grades. Moreover, the proportion of CD44+/CD24-/low tumor cells in the DCIS components of IDC and DCIS might harbor different biology, which may lead to differences in cancer progression and early carcinogenesis.
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KEYWORD
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Neoplastic stem cells, CD44 protein, human, CD24 protein, human, Invasive ductal carcinoma, Carcinoma, intraductal, noninfiltrating
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